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MCI in PD: Movement Disorder Society Task Force report

January 25, 2012

An estimated 26.7% of patients with Parkinson’s disease experience mild cognitive impairment (MCI), according to a Movement Disorder Society task force report (Litvan et al. Mov Disord 2011; 26: 1814-1824). The estimated point prevalence of MCI is 30%; the estimated cumulative prevalence is >75% for PD patients surviving more than 10 years (Hely et al. Mov Disord 2008; 60: 387-392; Bronnick et al. J Neurol Neurosurg Psychiatry 2006; 77: 1136-1142…

Targeting IL-1b in epilepsy: VX-765

January 11, 2012

REPORT FROM THE AMERICAN EPILEPSY SOCIETY 65TH ANNUAL MEETING, BALTIMORE, MD, DECEMBER 2-6, 2011 – Animals studies have suggested that inflammation is a pathogenic factor in epilepsy, notably through the induction of caspase-1 and interleukin(IL)-1beta (Maroso et al. Neurotherapeutics 2011; 8: 304-315). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter wi…

Sudden unexpected death with lamotrigine: risk estimate

January 11, 2012

…HE AMERICAN EPILEPSY SOCIETY 65TH ANNUAL MEETING, BALTIMORE, MD, DECEMBER 2-6, 2011 – A Norwegian study estimates that the risk of sudden unexpected death in epilepsy (SUDEP) is 2.5 per 1000 patient-years in female patients receiving lamotrigine compared to 0.5 per 1000 patient-years in women not on lamotrigine (Aurlien et al. AES 2011; abstract 3.205). Subscribe to read more It takes 30 seconds or login using your email address Please enter the e…

Potassium channel activator useful in partial-onset seizures

December 14, 2011

…Retigabine (ezogabine in the U.S.), which activates KCNQ2/2 potassium channels, is effective as an adjunctive treatment in partial-onset seizures, according to the results of the phase III RESTORE 1 trial (French et al. Neurology 2011; 76: 1555-1563). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…