…A U.K. study reports that over one-third of patients with Parkinson’s disease develop neuropathy, which may be due to vitamin B12 deficiency arising from chronic levodopa exposure (Rajabally & Martey. Neurology 2011; 77:1947-1950). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…
An estimated 6-8% of PD patients treated with a dopamine agonist develop problem gambling, according to a new review of the literature (Djamshidian et al. Mov Disord 2011; 26: 1976-1984). Patients and their families need to be informed of the risks and to report any behavioural changes during treatment. Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter wi…
A number of prospective studies have suggested that elevated serum total homocysteine (tHcy), and low folate and vitamin B12 levels are a risk factor for Alzheimer’s disease (Clarke et al. Arch Neurol 1998; 55: 1449-1455). In the Prospective Population Study of Women in Gothenburg, elevated tHcy in midlife was associated with a hazard ratio of 2.1 for developing AD and 2.4 for AD with no cerebrovascular disease (Zylberstein et al. Neurobiol Aging…
…A majority of patients with psychiatric comorbidities secondary to tuberous sclerosis complex (TSC) respond to psychoactive medications, according to a single-centre analysis of clinical records (Chung et al. Ann Clin Psychiatry 2011; 23: 263-269). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…
Two novel compounds currently in development – bapineuzumab and solanezumab – for the treatment of Alzheimer’s disease expect to release phase III data in 2012. Those results may usher in a new era, or may add names to the list of high-profile setbacks in AD therapeutics such as tarenflurbil (Myriad), semagacestat (Lilly/Elan), tramiprosate (Neurochem) and AN1792 (Elan). Subscribe to read more It takes 30 seconds or login using your email address…