SPECIAL REPORT
It is now generally accepted that patients with relapsing-remitting multiple sclerosis will require more than one disease-modifying therapy (DMT) during their clinical course. Although a proportion of patients appear to be clinically stable on a platform therapy (beta-interferons and glatiramer acetate), it has been difficult to demonstrate the long-term benefits of this approach. A recent analysis of patients who initiated a DMT in the period 1995-2002 and received treatment for 13 years found no difference in time to onset of secondary-progressive MS (SPMS) between treated patients and untreated natural history cohorts (Coret et al. Mult Scler J Exp Transl Clin 2018;4:2055217318783347). Read More