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Always online: problem or addiction?

February 13, 2019

…n tools include Young’s Diagnostic Questionnaire for Internet addiction (8 questions) (Young 1998) and Internet Addiction Test (20 questions) (Young KS. New York: Wiley, 1998); Ko’s Diagnostic Criteria for Internet Addition for adolescents (3 criteria) (Ko et al. J Nerv Ment Dis 2005;193:728-733); and the Chen Internet Addiction Scale (26 items) (Chen et al. Chin J Psychol 2003;45:279-294). A further problem is that systematic reviews generally do…

Phase III trials in neurology – 2018 in review

January 24, 2019

…9:121; free full text at https://thejournalofheadacheandpain.biomedcentral.com/track/pdf/10.1186/s10194-018-0951-2). Two regimens were examined: 240 mg loading dose s.c. followed by 120 mg/month; and 240 mg/month s.c. In episodic migraine, ≥50% response was maintained for >3 months in 41.5% (120 mg) and 41.1% (240 mg) of patients in the galcanezumab groups versus 21.4% with placebo. Response was maintained for >6 months in 19.0% and 20.5% of patie…

Record number of FDA drug approvals in 2018

January 9, 2019

…ne (for a review see Holland & Goadsby. Neurotherapeutics 2018;15:304-312; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC5935646/pdf/13311_2018_Article_617.pdf). Epidiolex (cannabidiol, Greenwich Research) was approved in June as an antiseizure add-on therapy for patients with Lennox-Gastaut syndrome and Dravet syndrome. The drug is a liquid solution taken twice-daily in combination with other antiseizure medications. Approval was based o…

Rare cases of stroke reported with alemtuzumab

December 14, 2018

…erferon-gamma (Thomas et al. Neurol Neuroimmunol Neuroinflamm 2016;3:e228; free full text at www.ncbi.nlm.nih.gov/pmc/articles/pmid/27213173/). A cytokine storm was reported in the one patient who died of hemorrhagic stroke. Cytokine syndrome may manifest clinically as pyrexia, headache, malaise and urticarial rash, and may be associated with a transient worsening of neurological symptoms (Moreau et al. Brain 1996;119:225-237). The incidence of cy…

Improving QoL in patients with schizophrenia

December 5, 2018

…ore relevant in gauging a patient’s life improvement. Finally, there is a need for further treatment research into patients with psychosis comorbid with SUD so we can provide improved outcomes in this complex patient group. Dr. MacEwan is Clinical Professor, Department of Psychiatry, University of British Columbia, Vancouver, Canada….