…s. 36%). Real-world studies would be expected to enroll more patients with comorbid medical conditions, but few studies provided data on comorbidities. Back to top Clinical Tip of the day Women with RRMS who are contemplating pregnancy should be counselled to try to conceive during a period of relative clinical stability. An analysis of 335 pregnancies over a 5.7-year follow-up period found that a higher number of relapses in the year before pregn…

…Relapse risk was reduced 55% with active treatment. The proportion relapse-free at week 96 was 72.1% with satralizumab versus 51.2% with placebo. Back to top Cladribine and time to SPMS A post-hoc analysis of the CLARITY trial found that the proportion of patients who progressed to SPMS was 54% lower with cladribine 3.5 mg compared to placebo (6.7% vs. 13.5%) (Vermersch P. ECTRIMS 2019; abstract P385). A proxy definition of SPMS was used since SPM…