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Anti-CD20 therapies – Mechanisms of action

…Provides information on CD20, binding epitopes of anti-CD20 monoclonal antibodies (rituximab, ocrelizumab, ofatumumab, ublituximab) and the effects of anti-CD20 MAbs in multiple sclerosis. Includes slides explaining antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). 12 slides Download slide deck…

Variable vaccine efficacy against CoV-2 variants

…in (https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3). Some added protection may be obtained from a third vaccine dose, according to the results of the first posted study on booster injections. Subjects in the phase II and III studies of the Moderna mRNA-1273 vaccine were eligible for a booster dose administered 5.9-7.5 months after the second inoculation. The booster was eithe…

mRNA vaccines preferred: new NACI recommendation

…get (www.canada.ca/en/public-health/services/immunization/national-advisory-committee-on-immunization-naci/recommendations-use-covid-19-vaccines.html). The controversial recommendation states that an mRNA COVID-19 vaccine should be preferentially offered to individuals. The AstraZeneca COVID-19 vaccine may be offered to people aged >30 years only if the individual does not wish to wait for an mRNA vaccine. Individuals are advised to do their own b…

MS Clinics Network updates COVID vaccine guidance

…’Maison, Greenfield Park, Quebec, in an email to NeuroSens. “[T]here [are] data that some anti-CD20 drugs and S1P receptor agonists are associated with reduced SARS-Cov2 antibody responses with at least one of the mRNA vaccines. Similar data may emerge with other DMT or with other vaccines, but until then we would still recommend that all our patients get vaccinated regardless of the DMT they are using.” The statement was provided by Dr. Grand’Mai…