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Thrombotic risk and COVID-19 vaccines: new data and disputes

April 29, 2021

…6 April 2021; www.the-scientist.com/news-opinion/blood-clot-risk-from-covid-19-higher-than-after-vaccines-study-68675). It should be noted that the thrombotic complications linked to COVID vaccination are, in part, a subset of CVT that occur in the setting of thrombocytopenia, a syndrome that has been labelled vaccine-induced prothrombotic immune thrombocytopenia (VIPIT, or VITT). The CDC’s Advisory Committee on Immunization Practices has analysed…

Are trial data generalizable to MS population?

April 27, 2021

…I clinical trial of the treatment they were taking. Only 4.0% of interferon-treated patients, 7.6% of ocrelizumab-treated patients and 12.0% of cladribine-treated patients met the entry criteria for their respective clinical trials. The largest proportion of patients meeting trial criteria was the fingolimod group (27.7%). The relapse criterion used in trials, typically >1 relapse in the previous year or >2 relapses in the previous two years, was…

COVID variants: is one dose better than nothing?

April 26, 2021

…w for prolonged viral shedding (www.gov.uk/government/publications/sars-cov-2-immunity-escape-variants-7-january-2021). Resistance to COVID-19 therapies is akin to antibiotic resistance, in that resistant strains exposed to an anti-infective environment emerge due to selective pressure. This has already been seen with some treatments for COVID-19. A single point mutation is sufficient to produce resistance (e.g. E484K) to monoclonal antibodies use…

Few vaccine responders with fingolimod, ocrelizumab

April 23, 2021

…primary-progressive (19.2%) and RIS/CIS (5.6%) patients. An ELISA anti-SARS-CoV-2 IgG immunoassay was performed 4-6 weeks after the second vaccine dose. Patients in the fingolimod group (n=26) were currently on treatment during the vaccination period in accordance with the current vaccine guidance. Median age was 44.9 years; 46.2% were female; median disease duration was 15.7 years; and median EDSS score was 2.0. The proportion of patients with a…

AAN Daily Reports – Wednesday, April 21 edition

April 21, 2021

…gistry (N=46,128) now suggests that UV-B exposure is associated with MS severity as well as susceptibility (Vitkova M. AAN 2021; P.112). The MS Severity Scale (MSSS) was used to quantify disease severity. UV-B exposure was calculated from ozone mapping data obtained from NASA. Cumulative follow-up was >351,000 patient-years. The study found higher MSSS scores above 40 degrees latitude (which runs through New York City, Madrid, Naples, Thessaloniki…