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ECTRIMS 2021 HIGHLIGHTS – WEDNESDAY, OCTOBER 13 EDITION

…D patients were six-fold more likely to have a poor outcome compared to non-comorbid patients. RIS: stratifying risk of progression An analysis of the RelevarEM MS/NMOSD registry in Argentina (n=88) reported that patients with radiologically isolated syndrome with two or three risk factors were at high risk of progression to CIS/MS (Rojas et al. ECTRIMS 2021; abstracts P006 and P009). Over the 40-month follow-up period, 44.3% showed a new MRI lesi…

ECTRIMS 2021 POSTER PICKS – DAY 1

…n=111). Results: Mean annualized relapse rate was 0.20; 72-73% were relapse-free 82-90% of patients did not have sustained EDSS worsening by week 192. Conclusion: Long-term efficacy of satralizumab appears to be sustained. P032 – COVID-19 in neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody disease patients in North America; COViMS registry S.D. Newsome et al. Objective: To determine COVID-19 outcomes in pati…

DMTs and vaccine response in MS: the evidence to date

…eported to reduce the likelihood of generating an antibody response to SARS-CoV-2 infection in two recent studies (van Kempen et al. JAMA Neurol 2021;78:880-882. Conte WL. Mult Scler Relat Disord 2021;52:103014), which is consistent with what has been previously reported (Zabalza et al. Eur J Neurol 2020, epublished 19 December 2020). A case series of 15 MS patients receiving cladribine or alemtuzumab reported a CoV-2 IgG response in 100% (4 of 4)…

Secondary-progressive multiple sclerosis (SPMS)

…Provides information on SPMS diagnosis, active and progressive sub-phenotypes, time to SPMS in historical and contemporary cohorts, age and EDSS score as predictors of SPMS, and patients’ symptom that may herald the transition to SPMS. 10 slides Download slide deck…

New failed trials of intrathecal rituximab in PMS

…VITALISE study, IV + IT rituximab failed to deplete B cells in CNS tissue (-10% to -20%) despite significant B cell depletion in CSF (-79%). NfL levels were unchanged. Similar results were seen in a small study of intrathecal rituximab (2 x 25 mg two weeks apart) in MS patients with meningeal inflammation (Bhargava et al. Mult Scler Relat Disord 2019;30:136-140). Rituximab had no demonstrable effect on leptomeningeal enhancing lesions over the 24-…