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COVID variants: is one dose better than nothing?

April 26, 2021

…ach added, “we could be wrong.” (Serebrin J. Canadian Press, 2 March 2021. www.thestar.com/news/canada/2021/02/03/fear-that-delayed-second-covid-19-vaccine-dose-could-lead-to-new-variants-realistic.html). How these variants have emerged has not been determined. The pandemic strain (D614G) is a variant that supplanted the Wuhan strain and soon became dominant due to enhanced infectivity of the upper respiratory tract (Plante et al. Nature 2021;592:…

Few vaccine responders with fingolimod, ocrelizumab

April 23, 2021

…ive humoral response. Ocrelizumab-treated patients who are not at high risk of severe COVID are advised to postpone vaccination for at least 9 months after the last dose. Free download of the full paper by Achiron et al. at https://journals.sagepub.com/doi/pdf/10.1177/17562864211012835….

AAN 2021 Poster Picks – Day 2

April 20, 2021

…s – Day 3 AAN 2021 Poster Picks – Day 1 Poster 076 – Long Term Efficacy Outcomes with Inebilizumab Treatment in NMOSD: the N-MOmentum Trial Bruce A. C. Cree, MD, PhD Objective: Evaluate the long-term efficacy of inebilizumab in neuromyelitis optica spectrum disorder. Data source: Open-label extension (up to 2 years) of the phase II/III N-MOmentum trial of inebilizumab 300 mg IV vs. placebo (Cree et al. Lancet 2019;394:1352-1363). Interim analysis…

COVID vaccination: is one dose better than nothing?

April 13, 2021

…U/mL only after the second dose (Mulligan et al. Nature 2020;586:589-593. www.nature.com/articles/s41586-020-2639-4.pdf). However, RBD-binding IgG titres were not substantially lower than what was seen in patients who had recovered from COVID-19 or had received convalescent serum (602 U/mL). It has not been determined if antibody levels following a single dose will be sustained for up to 16 weeks, or if delaying the second dose will impair the ov…

Early, effective MS treatment revisited

April 8, 2021

…irst-choice agents? Yes No Unsure Do you think you will be more likely to escalate a patient to a higher-efficacy DMT once that patient has received their full COVID-19 vaccination? Yes No Unsure If COVID-19 becomes endemic and/or variants become more prevalent, do you think you will reduce your use of higher-efficacy DMTs in older patients to maintain immune competence (e.g. >55 years)? Yes No Unsure…