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Third failed trial for solanezumab in AD

February 22, 2018

…ally offset the adverse effects of longer forms (e.g. Aβ42). Thus, indiscriminately reducing all beta-amyloid forms may worsen cognition in patients with a low baseline beta-amyloid load (Geerts et al. Alzheimers Res Ther 2018;10:14; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC5797372/pdf/13195_2018_Article_343.pdf). As such, the authors offer the counterintuitive suggestion that amyloid-lowering agents may actually worsen cognition out…

ECTRIMS/EAN publish new MS treatment guidelines

January 30, 2018

…7751049). The groups identified 10 key questions, and issued a series of recommendations based on the level of evidence. The following is a summary of the groups’ recommendations. Therapeutic intervention 1- All DMDs should be prescribed only in centres with adequate infrastructure to provide proper patient monitoring, comprehensive assessment, detection of side effects and the capacity to address them promptly. 2- Clinically isolated syndrome: Of…

2017 U.S. drug approvals in neurology and psychiatry

January 19, 2018

…ients (Writing Group, et al. Lancet Neurol 2017;16:505-512). Adjuvanted, recombinant varicella zoster vaccine (Shingrix, GlaxoSmithKline): while not a neurology/psychiatry drug, zoster vaccines are becoming routine in the treatment of MS patients scheduled for a course of immunosuppressants. The vaccine was approved for the prevention of shingles in adults >50 years. Of interest is that it is a non-live vaccine, in contrast to Zostavax, a live-att…

Vortioxetine: Improved work productivity in adults with major depression

December 13, 2017

…(Schatzberg et al. J Clin Psychiatry 2014;75:1411-1418; free full text at www.psychiatrist.com/JCP/article/_layouts/ppp.psych.controls/BinaryViewer.ashx?Article=/jcp/article/Pages/2014/v75n12/v75n1209.aspx&Type=Article). In the study by Katona and colleagues, elderly subjects (mean age 70.6 years) treated with vortioxetine 5 mg/day showed improved processing speed, verbal learning and memory on cognitive testing (Katona 2012). The reference agent…

Cladribine tablets – Updated efficacy and safety results

November 28, 2017

…cy, Summary of product characteristics, August 22, 2017. Free full text at www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/004230/WC500234561.pdf No head-to-head trials have compared cladribine tablets with other disease-modifying therapies. To date, only one preliminary study from the MSBase group has examined this issue using a propensity score-matched analysis (Kalincik et al. ECTRIMS 2017; abstract P1138). The da…