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Neurological sequelae of COVID-19 infection

April 19, 2022

…of acute neurological complications of COVID-19 infection, as well as long-term complications, variously called PASC (post-acute sequelae of COVID-19) or ‘long COVID’. Data were reported at the American Academy of Neurology annual meeting, held April 2-7 in Seattle, Washington. An analysis of the Society of Critical Care Medicine’s multinational Viral Infection and Respiratory Illness University Study (VIRUS) database of confirmed COVID-19 infect…

AAN 2022 HIGHLIGHTS – WEDNESDAY, APRIL 6 EDITION

April 6, 2022

…a, termed the spinal cord reserve, is associated with better disability outcomes (Sastre-Garriga et al. AAN 2022;S26.006). A total of 3172 3T MRI scans of brain down to C5 were analysed. Spinal cord area was significantly lower in MS patients versus controls (60.35 vs. 65.02 mm2), as was the spinal cord parenchymal fraction (0.28 vs. 0.31). A larger spinal cord canal area was significantly associated with a lower score on the Patient-determined Di…

AAN 2022 HIGHLIGHTS – TUESDAY, APRIL 5 EDITION

April 5, 2022

…d with seroconversion. MS and pregnancy An analysis of the Canadian CANPREG-MS and U.S. PREG-MS longitudinal studies found that the rate of pregnancy in woman planning a pregnancy was lower in MS patients compared to the general population (Houtchens et al. AAN 2022;P9.009). The study enrolled 129 women during pregnancy planning. There were 102 conceptions during the observation period; 73.5% were viable and 26.5% were pregnancy losses. Overall, 5…

Ofatumumab safety update: modest effect on Ig

March 25, 2022

…ns, October 21, 2021). The analysis included patients in ALITHIOS, the long-term safety study comprising subjects from the pivotal ASCLEPIOS I/II trials, the APLIOS bioequivalence study and the phase II APOLITOS study in Japanese and Russian MS patients (Saida et al. AAN 2021; abstract 2032). The safety population included patients treated with continuous ofatumumab and switch patients (total N=1969). Mean age was 38.7 years; mean time from diagno…