An international consortium has published its recommendations on issues relating to deep brain stimulation (DBS) in patients with Parkinson’s disease (Bronstein et al. Arch Neurol 2010; epublished October 11, 2010).
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White matter hyperintensities predict cognitive decline
February 23, 2011White matter hyperintensities are a predictor of cognitive decline in relatively healthy older subjects, according to data from the Alzheimer Disease Neuroimaging Initiative (Carmichael et al. Arch Neurol 2010; 67: 1370-1378).
MoCA recommended to detect cognitive dysfunction in Parkinson’s disease
February 23, 2011The task force of the Parkinson Study Group Cognitive/Psychiatric Working Group has recommended the Montreal Cognitive Assessment (MoCA) as the most suitable tool to detect mild cognitive impairment (MCI) in patients with Parkinson’s disease (Chou et al. Mov Disord 2010; 25: 2501-2507). The task force further recommended that the MoCA be employed in clinical trials of PD where the primary outcome is not cognitive performance.
The J-curve: is lower BP better?
February 23, 2011The Joint National Committee on Prevention,Detection, Evaluation, and Treatment of High Blood Pressure(JNC-7) recommends aggressive blood pressure lowering to prevent cardiovascular outcomes (Chobanian et al. JAMA 2003; 289: 2560-2572; free full text at http://jama.ama-assn.org/cgi/reprint/289/19/2560?ijkey=c099fcb433c2980de606feca9dfb451112a828ed). In its classification scheme, JNC-7 regards BP < 120/80 to be normotensive, and systolic BP 120-139 mmHg or diastolic BP 80-89 mmHg to be pre-hypertensive. The increasing risk of cardiovascular events is considered to be continuous above 115/75 mmHg.