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No gain with higher dose of glatiramer acetate

 

A higher dose of glatiramer acetate appears to be well tolerated but does not provide improved efficacy over standard dosing, according to the results of the FORTE study (Comi et al. Ann Neurol 2011; 69: 75-82).

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PD progression, QOL impairments less in females

 

Disease progression in patients newly-diagnosed with Parkinson’s disease is less pronounced in females but more severe in older subjects, according to data from the Co-morbidity and Ageing in Rehabilitation Patients; the influence on Activities (CARPA) study group (Post et al. Mov Disor 2011; 26: 449-456).

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AD progression associated with elevated coated platelet level

 

Coated platelets are a subset of platelets produced by activation with both collagen and thrombin and which retain intact amyloid precursor protein on their surface (Prodan et al. Platelets 2006; 17: 56-60). It has been suggested that coated platelets may play a role in the alteration in amyloid precursor protein metabolism in Alzheimer’s disease.

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