REPORT FROM THE ENS 2008 – Zonisamide (Zonegran) is a sulfonamide anticonvulsant used as an adjunctive therapy in epilepsy.
Neurology
PROCESS study of spinal cord stimulation: 24-month data
October 8, 2008REPORT FROM THE ENS 2008 – The Canadian PROCESS study compared spinal cord stimulation (SCS) plus conventional medical management (CMM) to CMM alone in 100 patients with predominant neuropathic leg pain secondary to failed back surgery syndrome (Kumar et al. Pain 2007;132:179-188).
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LDL targets not met with statins post-stroke
October 7, 2008REPORT FROM THE ENS 2008 – The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial demonstrated that atorvastatin 80 mg/day was effective in secondary prevention of ischemic stroke or TIA. At 4.9-year median follow-up, the absolute risk reduction for ischemic stroke with atorvastatin versus placebo was 2.2% (adjusted HR 0.78), although more hemorrhagic strokes occurred in the active treatment group (55 vs. 33; adjusted HR 1.66) (Amarenco et al. N Engl J Med 2006;355:549-59).
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Beta-interferons in CIS: Cochrane meta-analysis
September 23, 2008REPORT FROM THE ENS 2008 – Beta-interferons are effective in preventing the conversion of clinically isolated syndrome (CIS) suggestive of MS to clinically definite MS, according to the results of a Cochrane meta-analysis (Clerico et al. Abstract 0160. J Neurol 2008;255(suppl 2): 37; published as Clerico et al. Cochrane Database Syst Rev 2008;April 16(2):CD005278).
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Functional neuroimaging of vascular parkinsonism
September 23, 2008REPORT FROM THE ENS 2008 – Functional imaging is potentially useful in the differential diagnosis of vascular parkinsonism but larger studies are needed to identify the optimal methodology, according to a literature review presented at the ENS (Kalra et. al. Abstract P798. J Neurol 2008;255(suppl 2): 198).