Pioglitazone not effective in PD


Pioglitazone is a PPAR (peroxisome proliferator-activated receptor)-gamma agonist of the thiazolidinedione class that is used to treat insulin resistance in patients with Type 2 diabetes. Prior studies in the MPTP mouse model reported that the drug prevented dopaminergic cell loss in the substantia nigra (Breidert et al. J Neurochem 2002;82:615-624). The implication was that the drug might be usefully employed as a neuroprotective agent in Parkinson’s disease.

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