Report from the 1st Congress of the European Academy of Neurology, Berlin, Germany, June 20-23, 2015 – Subcutaneous apomorphine is clinically available in many countries for the acute treatment of Off periods in PD. Alternative delivery methods have been investigated for several decades.
A new sublingual formulation, APL-130277, by a Canadian drugmaker has now completed early open-label phase IIa testing and results are available (Hauser et al. EAN 2015; abstract P2153). Read More
Report from the 1st Congress of the European Academy of Neurology, Berlin, Germany, June 20-23, 2015 – Imaging and CSF biomarkers of neurodegeneration appear to be correlated only in patients with Alzheimer’s disease with beta-amyloid pathology, according to a study by the Alzheimer’s Disease Neuroimaging Initiative (Andriutal et al. EAN 2015;O3102). Read More
Report from the 1st Congress of the European Academy of Neurology, Berlin, Germany, June 20-23, 2015 – Few studies have examined the feasibility of switching MS patients from one higher-efficacy therapy to another. In the TOFINGO and ENIGM (Enquête Nationale sur l’Introduction du Fingolimod en Relais au Natalizumab) prospective studies, disease reactivation was generally well controlled after switching from natalizumab to fingolimod, most notably when the washout period did not exceed 12 weeks (Kappos et al. Neurology 2015; epublished May 29, 2015; Cohen et al. JAMA Neurol 2014;71:436-441).
The MSBase study group has recommended a maximum 8-week washout period (Jokubaitis et al. Neurology 2014;82:1204-1211). Read More
Report from the 1st Congress of the European Academy of Neurology, Berlin, Germany, June 20-23, 2015 – There is an implied association between psoriasis and multiple sclerosis, as evidenced by an increased incidence of psoriasis in MS patients, and the efficacy of psoriasis treatments such as fumarates in MS. The relationship between psoriasis and MS was explored further in a retrospective database analysis from a single MS centre in Israel (Miron et al. EAN 2015; F2168). Read More