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1 dead in phase I trial

 

One person is dead and five others are hospitalized in a phase I trial that went badly wrong. Three of the survivors may have suffered irreversible brain damage, according to Dr. Gilles Edan, head of neurology at the Centre Hospitalier Universitaire de Rennes, France, as quoted in the New York Times (Chanjan S. NY Times, Jan. 15, 2016). Preliminary MRI results showed cerebral hemorrhage and brain necrosis in some study participants. Read More

Increased cardiovascular risk in Parkinson’s disease

 

Patients with Parkinson’s disease have a significantly elevated risk of acute myocardial infarction and cardiovascular death, according to a population-based longitudinal study (Liang et al. Am Heart J 2015;169:508-514). The analysis included 3,211 PD patients and 3,211 propensity score-matched subjects without PD. During the three-year follow-up, there were 83 fatal or non-fatal AMIs in the PD group compared to 53 in the non-PD group (hazard ratio 1.67). There were also significant differences in the PD versus non-PD groups for the combined endpoint of AMI or cardiovascular death (HR 1.46), and for AMI or all-cause mortality (HR 1.42). Read More

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