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EAN HIGHLIGHTS 2023 – TUESDAY, JULY 4 EDITION

July 4, 2023

…s) IgG antibody response post-vaccination. Eighty percent demonstrated a 10-100-fold increase in anti-S1/S2 antibody levels, suggesting that evobrutinib does not impair the humoral response to vaccination. Remibrutinib is a BTK inhibitor in development for MS and various autoimmune disorders. A pooled analysis of safety data from phase II trials in chronic spontaneous urticaria, Sjogren syndrome and asthma (n=363) reported no increase in infection…

EAN HIGHLIGHTS 2023 – MONDAY, JULY 3 EDITION

July 3, 2023

…42% experienced a relapse during follow-up. The likelihood of being relapse-free was 90% if both the kFLC index and NfL z-score were low; 70% with low kFLC index and high sNfL z-score; 30% with high kFLC index and low sNfL z-score; and 2% if both were high. When does PIRA start? Patient age and relapses are the dominant drivers of progression independent of relapse activity (PIRA), according to an analysis of the Italian MS registry (n=3777) (Iaff…

NEUROLOGY NEWS IN BRIEF – JUNE 2023

June 27, 2023

…rosci Rep 2023;23:389-398. https://link.springer.com/article/10.1007/s11910-023-01278-y Multiple sclerosis Results from the DISCOMS discontinuation trial have now been published. Treatment discontinuation in patients aged >55 years was non-inferior although the rate of relapses/new T2 lesions was higher in the discontinuation group (12.2% vs. 4.7%) (Corboy et al. Lancet Neurol 2023;22:568-577). www.sciencedirect.com/journal/the-lancet-neurology/vo…

Novel approach to MS therapeutics: anti-CD40L

June 21, 2023

…4. The change from baseline in plasma neurofilament-light (NfL) levels was -26% and -20% in the higher- and lower-dose dose groups, respectively, versus placebo at week 12. No serious adverse events were reported. The most common adverse effects were COVID-19 infection (mild to moderate) and headache. There was one case of elevated liver enzymes. Other potential applications of anti-CD40L MAbs include autoimmune and neuroinflammatory conditions su…

CLINICAL CASES IN MS – A case of worsening mobility during the pandemic

June 13, 2023

…ne was stable. At her most recent visit, Michelle said she has been relapse-free but has been experiencing worsening symptoms (e.g. bladder issues). She has been having difficulty concentrating which had caused problems at work. She said that her mobility has worsened, and she can only walk 300 metres unaided. MRI is unchanged. The survey is now closed. We received 30 responses. See below for a summary of the answers you provided. Question 1: In y…