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Inertia and uncertainty: is MS treatment truly optimized?

 

SPECIAL REPORT

Numerous head-to-head trials in multiple sclerosis have demonstrated the benefits of treatment with a higher-efficacy versus modest-efficacy disease-modifying therapy (DMT). Examples include the TRANSFORMS (fingolimod vs. interferon-b), CARE-MS (alemtuzumab vs. interferon-b), OPERA I/II (ocrelizumab vs. interferon-b), and ASCLEPIOS I/II (ofatumumab vs. teriflunomide) trials in relapsing MS. Read More

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New guidance on use of sNfL in practice

 

An international panel of experts in conjunction with the Consortium of MS Centers (CMSC) has developed recommendations on the use of neurofilament-light chain (NfL) as a biomarker of disease activity in multiple sclerosis (Freedman et al. eBioMedicine 2024;101:104970). Read More