Erenumab (Aimovig), a monoclonal antibody targeting the calcitonin gene-related peptide (CGRP) receptor, has received Health Canada approval for the prevention of migraine in adults who have at least four migraine days per month. This would include patients with episodic (< 15 headache days/month) and chronic migraine (>15 headache days/month, of which >8 are migrainous). The drug is administered by subcutaneous injection once a month. The recommended dose is 70 mg (one injection) per month. Some patients may benefit from a dose of 140 mg qmonthly, administered as two consecutive 70-mg injections. The drug is provided in an autoinjector for patients to self-administer. Read More
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Predictors of switching therapies in MS – real-world results
August 1, 2018An analysis of data from 24 Italian MS centres has identified factors associated with an early change of disease-modifying therapy (Sacca et al. Mult Scler 2018; epublished July 25, 2018). Read More
Inhibiting CGRP in migraine prophylaxis
July 25, 2018SPECIAL REPORT
60th Annual Scientific Meeting of the American Headache Society, San Francisco CA, 29 June – 1 July 2018 – Erenumab, the first in a new class of monoclonal antibodies that inhibit calcitonin gene-related peptide (CGRP), has now been approved in the U.S. Other agents in development are fremanezumab, eptinezumab and galcanezumab. The following is a summary of new data on these agents presented at the 60th annual meeting of the American Headache Society. Read More
Emerging approach to improve functional recovery post-stroke
July 18, 2018A large database analysis has reported that histone deacetylase (HDAC) inhibition may be beneficial in the secondary prevention of ischemic stroke (Brookes et al. Stroke 2018;49:54-61). Read More