Emerging approach to improve functional recovery post-stroke


A large database analysis has reported that histone deacetylase (HDAC) inhibition may be beneficial in the secondary prevention of ischemic stroke (Brookes et al. Stroke 2018;49:54-61).

The study used data from three long-term stroke studies: the South London Stroke Register (SLSR); the Vitamins to Prevent Stroke (VITATOPS) study; and the Oxford Vascular Study (OXVASC) (combined n=11,949). The objective was to determine if the antiepileptic drug sodium valproate, a nonspecific HDAC inhibitor, was associated with a reduced risk of recurrent stroke.

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