…ine if there are common features (Sinyor et al. Can J Psychiatry 2014;59:26-33). The sample included 2,886 cases from 1998-2010 in which the coroner ruled that the death was due to suicide. Five clusters were identified based on individual and suicide-specific factors. Cluster 1 included primarily women; all had depression, a history of prior suicide attempts, and used a nonviolent method. Cluster 2 was exclusively married individuals who had expe…
…levels had a 40% lower rate of PD (Davis et al. Am J Epidemiol 1996;144:480-484; free full text at http://aje.oxfordjournals.org/content/144/5/480.long). This association between higher serum urate and lower PD risk was also seen in the Health Professionals Follow-up Study (Weisskopf et al. Am J Epidemiol 2007;166:561-567; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC2391073/pdf/nihms44448.pdf; Gao et al. Am J Epidemiol 2008;167:831-838;…
…atients receiving fingolimod for up to three years, two-thirds were relapse-free both in year 1 and year 2 of treatment. The average EDSS score was stable. The discontinuation rate was 12.7%; the most common reason for discontinuation was adverse effects (4.5%). At 24 months, 98% of clinicians and patients rated treatment tolerability as very good/good. Teriflunomide: The long-term safety of teriflunomide was analysed with 12-year extension data f…
…d at 24 hours (44% vs. 24%) and 48 hours (34% vs. 20%). One-third were pain-free at two hours post-dose with active treatment compared to 17% with placebo. The proportion achieving meaningful pain relief at two hours was 70% with intranasal sumatriptan versus 45% with placebo, according to patient self-rating. Fewer patients on active treatment required rescue medications (37% vs 52%). One patient receiving intranasal sumatriptan reported mild par…
…ving fingolimod 0.5 mg in the FREEDOMS and FREEDOMS II trials achieved NEDA-4 compared to 5.3% receiving placebo (odds ratio 4.41) (Kappos et al. ECTRIMS 2014; abstract FC1.5). (New/enlarging T2 lesions but not new Gd-enhancing lesions were used for the MRI component.) A new post-hoc analysis of data from the two phase III studies has examined the NEDA-4 rate in the subset of patients with high disease activity at study entry, defined as >1 relaps…