A new head-to-head trial has reported that nonmyeloablative hematopoietic stem-cell transplantation is superior to disease-modifying drugs (DMD) with respect to time to disease progression in patients with highly-active relapsing-remitting multiple sclerosis (Burt et al. JAMA 2019;321:165-174). Read More
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FDA approves migraine drug for cluster headaches
June 12, 2019Galcanezumab, a calcitonin gene-related peptide (CGRP) antagonist, is the first agent to receive FDA approval for the treatment of cluster headaches. The product was accorded a priority review in March and a ruling had been expected later this year. Galcanezumab is marketed as Emgality in the U.S. and received approval for the prevention of migraine last year. It is the third CGRP-targeted monoclonal antibody for migraine prophylaxis after erenumab (Aimovig) and fremanezumab (Ajovy). Aimovig, which uniquely targets the CGRP receptor, has also received approval by Health Canada for migraine prevention. Read More
Switching therapies in MS – what is the evidence?
May 28, 2019SPECIAL REPORT
It is now generally accepted that patients with relapsing-remitting multiple sclerosis will require more than one disease-modifying therapy (DMT) during their clinical course. Although a proportion of patients appear to be clinically stable on a platform therapy (beta-interferons and glatiramer acetate), it has been difficult to demonstrate the long-term benefits of this approach. A recent analysis of patients who initiated a DMT in the period 1995-2002 and received treatment for 13 years found no difference in time to onset of secondary-progressive MS (SPMS) between treated patients and untreated natural history cohorts (Coret et al. Mult Scler J Exp Transl Clin 2018;4:2055217318783347). Read More
AAN 2019 DAILY REPORT
May 9, 2019Report from the American Academy of Neurology annual meeting, Philadelphia, PA, May 4-10, 2019
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