NfL a marker of microglial activation
December 6, 2023…ts suggest that sNfL may also be a marker of smouldering disease since patients had no recent Gd+ lesions and had been relapse-free for >5 years. …
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Biomarkers after stopping treatment may identify at-risk MS patients
November 30, 2023…icacy DMT. Two of three previous discontinuation trials enrolled patients aged 55+ years (DISCOMS) or >50 years (STOP-I-SEP)….
Exploring the lung-brain axis in MS
November 29, 2023…the healthy lung was traditionally considered to be a sterile site, new non-culture-based techniques (e.g. 16S RNA gene sequencing) have shown that lungs are chronically colonized by a low biomass of micro-organisms (~106 organisms). A further suggestion is that this lung microbiome, like the gut microbiome, may contribute to MS pathogenesis. Evidence for this hypothesis largely derives from a series of animal studies. The first study examined ent…
Neurofilament-light chain (NfL) as a biomarker of response to higher-efficacy disease-modifying therapies
November 22, 2023…Includes data on NfL changes after initiation of fingolimod, ofatumumab, ocrelizumab, natalizumab, alemtuzumab and oral cladribine. 11 slides Download the slide deck…
OCT – diagnosis and prognosis
November 8, 2023…patients presenting with a first episode of demyelination. Over a mean four-year follow-up, 30% were diagnosed with MS. Predictors of MS conversion were lower peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell and inner plexiform layer (GCIPL) thickness. Proposed cut-off values were pRNFL <98 µm and GCIPL <68 µm. McDonald 2017 DIT criteria (OCB, MRI) were not predictive of MS conversion. The authors suggested that OCT markers would…