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Cognitive function in PD: gender effect?

August 20, 2014

…impairment, REM behaviour disorder, orthostatic hypotension and sexual dysfunction, were more common in men. A separate review has examined the impact of gender on cognitive function and emotions (Heller et al. Aging Dis 2013;5:63-75; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3901615/pdf/ad-5-1-63.pdf). Overall, cognitive dysfunction appeared to be more common in males, although the authors noted that test results are inconsistent. M…

Amyloid-beta in CSF: meta-analysis of accuracy in diagnosis

August 20, 2014

…l. Transl Neurosci 2013;4:10.2478; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3873720/). They further noted that ELISA kits for amyloid-beta1-42 (and for t-tau) produced by different manufacturers will not have the same results and should not be used interchangeably. Comment Dr. Yves Bacher: Biomarkers will probably become more and more useful in the case of early-onset dementia, strong familial history, MCI management and atypical pre…

Long-acting injectable aripiprazole approved in Canada

August 13, 2014

…16:917-925; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3709884/pdf/JME-16-917.pdf). These clinical benefits of relapse reduction and fewer in-patient stays may be attributable in part to the more stable drug levels achievable with LAIs and to improved rates of treatment adherence and persistence. In the long-term open-label extension of aripiprazole OM phase III studies, 79.4% of patients remained on treatment at one year, with few pat…

Sleep disorder in PD: a role for circadian rhythm disturbance?

August 6, 2014

…3;8:e81802; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3849275/pdf/pone.0081802.pdf). A novel suggestion is that disturbances to circadian rhythm may play a role in sleep-wake disturbances in PD. To investigate this, a cross-sectional study monitored serum melatonin levels in 20 PD patients on stable dopaminergic therapy and 15 age-matched controls (Videnovic et al. JAMA Neurol 2014; epublished February 24, 2014). Melatonin levels were…

New dosing for glatiramer acetate

August 6, 2014

…ed that a regimen of glatiramer acetate 20 mg administered every other day compared favourably with once-daily dosing (Flechter et al. Clin Neuropharmacol 2002;25:11-15). Moreover, a two-year prospective study comparing glatiramer acetate 20 mg OD versus 20 mg twice-weekly showed no difference between the two dosing schedules with respect to ARR, EDSS, proportion of patients relapse-free and number of T1 and T2 lesions (Caon et al. AAN 2010; abstr…