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Serotonergic mechanisms in PD: two reports

December 10, 2014

…:1340-1349; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3934188/pdf/JCI71640.pdf). PD patients with LIDs demonstrate higher synaptic levels of dopamine compared to non-dyskinetic patients due to abnormal release and clearance of striatal dopamine, and it was hypothesized that this may be due in part to dopamine storage and release by non-dopaminergic terminals. Serotonergic terminals were a candidate for having a role in mishandling exo…

Future uncertain for active immunotherapies in AD – Part 1

December 10, 2014

…1), which disrupts cleavage of amyloid precursor protein and beta-amyloid formation. A combination trial was announced in July 2014 in subjects at risk of developing AD (media release at www.novartis.com/newsroom/media-releases/en/2014/1824651.shtml). To date, BACE1 inhibitors have had a mixed track record. A phase II trial of LY2886721 was terminated due to hepatotoxicity, although it is unclear if liver effects were related to its anti-BACE eff…

Toward a new standard in MS disease control

October 22, 2014

…onal 13.6-14.6 months to reach that degree of brain volume loss during the FREEDOMS/FREEDOMS II extensions. The amount of time gained versus IFNb-1a in the TRANSFORMS study was 5.6 months with continuous fingolimod. In LONGTERMS, the open-label extension of phase II and III trials of fingolimod, a comparison of patients on continuous fingolimod versus placebo-fingolimod showed that mean percentage brain volume change (PBVC) was significantly lower…

Poor adherence to migraine prophylaxis

October 8, 2014

…madan et al. Free full text at http://tools.aan.com/professionals/practice/pdfs/gl0090.pdf). Data were analysed for the rates of adherence and persistence. Adherence referred to how well a patient took a medication as prescribed (timing, dose, frequency), as determined by pill counts, the medication possession ratio (MPR), or other method. Persistence was the amount of time that a patient remained on a medication, as determined by trial discontinu…

Combining drug and psychotherapy more effective for depression, anxiety

September 24, 2014

…ent evidence with respect to dysthymia, PTSD and GAD. The dropout rate was comparable with combined treatment and drug treatment alone. In examining either therapy alone and combined treatment versus placebo, the analysis found that the effects of psychotherapy and pharmacotherapy were largely independent of one another, with each contributing about 50% of the total treatment effect. Thus, there appears to be an additive benefit when a combination…