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Emerging Treatment Goals in Schizophrenia – Toward Functional Recovery

November 3, 2017

…7;20:40-49; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC5578804/pdf/pyw093.pdf). A separate analysis from QUALIFY found that the rate of sexual dysfunction was significantly lower with aripiprazole LAI versus paliperidone LAI (odds ratio 0.33 in men, 0.14 in women). Among those with baseline sexual dysfunction who improved with treatment, there was a corresponding trend to greater improvements in QLS total scores (Potkin et al. Int Clin…

ECTRIMS 2017 DAILY REPORT – SATURDAY EDITION

October 28, 2017

…erior to IFN-beta and similar to fingolimod with respect to the proportion free of disability progression, and was superior to all comparators with respect to proportion of patients with clinical disability improvement. The authors concluded that cladribine could be associated with superior recovery from disability compared to IFN-beta, fingolimod and natalizumab. Back to top Switching/sequencing studies Natalizumab to fingolimod or alemtuzumab: O…

ECTRIMS 2017 DAILY REPORT – THURSDAY EDITION

October 26, 2017

…s diagnosed at a younger age (4.3/1000 PY if age 20-40 years at diagnosis) compared to an older age (11.5/1000 PY if older than 40 years). These results support previous reports of higher mortality rates in patients with MS. Back to top NfL examined as potential biomarker Numerous biomarkers have been proposed for predicting conversion from CIS: OCBs, kappa free-light chain, IgG against neurotropic viruses, chitinase-3-like protein-1, soluble CD27…

Cladribine: intermittent immunosuppression in MS

September 21, 2017

…inhibiting DNA methylation (Schreiner & Miravalle. J CNS Dis 2012;4:1-14; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3619698/pdf/jcnsd-4-2012-001.pdf). This may be relevant to efficacy, as noted above, and to safety. Hypermethylation of tumour suppressor genes is known to promote some malignancies through gene silencing. The hypomethylating effects of cladribine have been demonstrated in leukemic cell lines (Wyczechowska et al. Bioche…

New findings on gut microbiome and MS

September 13, 2017

…itiative (McKay et al. Mult Scler Relat Disord 2017;12:1-3). For a recent review of the topic see Glenn & Mowry. J Interferon Cytokine Res 2016;36:347-357. Free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC5118957/pdf/jir.2015.0177.pdf….