The U.S. National Longitudinal Lesbian Family Study (NLLFS) is a large prospective cohort study of lesbian families and their children conceived through donor insemination (www.nllfs.org). Between 1986 and 1992, 154 lesbian mothers volunteered for the study with data collected through interviews and questionnaires. Additional data were obtained from offspring at ages 10 and 17 years through interviews. questionnaires and Child Behavior Checklists completed by the mother.
Latest News
Topiramate vs. phenytoin in new-onset epilepsy
December 8, 2010A 1-month trial comparing topiramate 100 mg/day versus phenytoin (1000 mg on day 1, 300 mg/day maintenance) in 261 patients with new-onset epilepsy has found that the two treatments are comparable. The primary objective of non-inferiority could not be established (Ramsay et al. Epilepsia 2010; 51: 1970-1977).
Trial of pramipexole for depression in PD
December 8, 2010A new study reports that the dopamine agonist pramipexole appears to have direct antidepressant effects in Parkinson’s disease patients with comorbid depression (Bxarone et al. Lancet Neurol 2010; 9: 573-580).
Clopidogrel in high vascular risk: CHARISMA substudy analysis
December 8, 2010The Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) trial randomized 15,603 patients at high vascular risk to clopidogrel 75 mg/day or placebo for 28 months to determine if the drug reduces the rate and severity of stroke (Hankey et al. Stroke 2010; 41: 1679-1683). All patients also received ASA. Results have now been published on a prespecified substudy examining the functional severity of stroke outcomes, as assessed by the modified Rankin Scale (mRS) three months post-stroke.