A Canadian/U.S. randomized controlled trial reports that patients with dementia with Lewy bodies (DLB) treated with risperidone or citalopram do not tolerate the medications and appear to obtain little benefit (Culo et al. Alzheimer Dis Assoc Disord 2010; epublished July 9, 2010). This is the first published trial to examine the effect of citalopram in DLB.
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Demyelination reported following HPV vaccination
October 18, 2010REPORT FROM THE 26TH CONGRESS OF THE EUROPEAN COMMITTEE FOR TREATMENT AND RESEARCH IN MS (ECTRIMS), GOTHENBURG, SWEDEN, OCTOBER 13-16, 2010 -Five new cases of acute CNS demyelination following immunization with the human papilloma virus vaccine (Gardasil®) have been reported by researchers in Greece (Balamoutsos et al. ECTRIMS 2010; P297). Four cases were diagnosed with a clinically isolated syndrome, and one case experienced repeated episodes of neurological dysfunction. In all cases, multiple demyelinating lesions were identified on brain and cervical spinal cord MRI and oligoclonal bands were present in CSF.
Need for early, aggressive treatment in RRMS
October 18, 2010REPORT FROM THE 26TH CONGRESS OF THE EUROPEAN COMMITTEE FOR TREATMENT AND RESEARCH IN MS (ECTRIMS), GOTHENBURG, SWEDEN, OCTOBER 13-16, 2010 – An aggressive approach to therapy earlier in the MS disease process appears to be generally preferable to an escalating treatment strategy, according to Dr. Giancarlo Comi, Milan, at a special session on current treatment approaches (ECTRIMS 2010; invited review 126).
New data on fingolimod in RRMS
October 18, 2010REPORT FROM THE 26TH CONGRESS OF THE EUROPEAN COMMITTEE FOR TREATMENT AND RESEARCH IN MS (ECTRIMS), GOTHENBURG, SWEDEN, OCTOBER 13-16, 2010 – The oral agent fingolimod consistently reduces relapse rates regardless of disease severity or treatment history, and drug discontinuation is not associated with significant clinical complications, according to new studies and analyses presented at ECTRIMS.