A pilot study of potential Alzheimer disease biomarkers has proposed that highly sensitive ELISA testing of amyloid levels in saliva may help to distinguish AD from other types of dementia at an early stage of the disease process (Bermejo-Pareja et al. BMC Neurol 2010; 10: 108).
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EDSS may underrepresent progression
January 12, 2011Researchers in the Netherlands report that combining different outcome measures in MS may be more useful in assessing disease progression than change in EDSS score alone (Kragt et al. Mult Scler 2010; epublished October 26, 2010). Clinical changes were assessed in 553 patients using EDSS, the Nine-Hole Peg test, the Timed 25-Foot walk, and the MS Impact Scale.
U.S. National Longitudinal Lesbian Family Study: two reports
January 12, 2011The U.S. National Longitudinal Lesbian Family Study (NLLFS) is a large prospective cohort study of lesbian families and their children conceived through donor insemination (www.nllfs.org). Between 1986 and 1992, 154 lesbian mothers volunteered for the study with data collected through interviews and questionnaires. Additional data were obtained from offspring at ages 10 and 17 years through interviews. questionnaires and Child Behavior Checklists completed by the mother.
Topiramate vs. phenytoin in new-onset epilepsy
December 8, 2010A 1-month trial comparing topiramate 100 mg/day versus phenytoin (1000 mg on day 1, 300 mg/day maintenance) in 261 patients with new-onset epilepsy has found that the two treatments are comparable. The primary objective of non-inferiority could not be established (Ramsay et al. Epilepsia 2010; 51: 1970-1977).