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Nicotine produces benefits in MCI

 

Administration of transdermal nicotine improves cognitive performance in patients with mild cognitive impairment (MCI), according to the results of a pilot study (Newhouse et al. Neurology 2012;78:91-101).

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Valproate: no benefit for clinical progression in AD

 

A large, multicentre study in moderate Alzheimer’s disease has found that valproate doesn’t delay the emergence of agitation or psychosis, and doesn’t have a significant effect on cognitive  decline (Tariot et al. Arch Gen Psychiatry 2011; 68: 853-861).

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Neuropathy in PD attributed to vitamin B12 deficiency

 

A U.K. study reports that over one-third of patients with Parkinson’s disease develop neuropathy, which may be due to vitamin B12 deficiency arising from chronic levodopa exposure (Rajabally & Martey. Neurology 2011; 77:1947-1950).

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