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Oral anti-alpha4-integrin in development

 

Firategrast, an oral formulation of a natalizumab-like small molecule, produces a significant reduction in MRI lesions, according to the results of a phase II study (Miller et al. Lancet Neurol 2012; epublished January 5, 2012).

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Nicotine produces benefits in MCI

 

Administration of transdermal nicotine improves cognitive performance in patients with mild cognitive impairment (MCI), according to the results of a pilot study (Newhouse et al. Neurology 2012;78:91-101).

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Valproate: no benefit for clinical progression in AD

 

A large, multicentre study in moderate Alzheimer’s disease has found that valproate doesn’t delay the emergence of agitation or psychosis, and doesn’t have a significant effect on cognitive  decline (Tariot et al. Arch Gen Psychiatry 2011; 68: 853-861).

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