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Breastfeeding not a sustainable therapy

 

REPORT FROM THE AMERICAN ACADEMY OF NEUROLOGY (AAN) ANNUAL MEETING, NEW ORLEANS LA, APRIL 21-28, 2012 – Studies to determine if exclusive breastfeeding reduces relapse frequency postpartum have produced conflicting results (Langer-Gould et al. Arch Neurol 2009;66:958-963; Portaccio et al. Neurology 2011;77:145-150; Nelson et al. JAMA 1988;259:3441-3443).

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Langer-Gould and colleagues have now followed 72 women with MS through their pregnancy and for 12 months postpartum to examine this issue further (Hellwig et al. AAN 2012; abstract P06.186).

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Exploratory study of higher carbidopa dosing

 

REPORT FROM THE AMERICAN ACADEMY OF NEUROLOGY (AAN) ANNUAL MEETING, NEW ORLEANS LA, APRIL 21-28, 2012 – The recommended doses of carbidopa (CD) to increase levodopa availability are in the range of 75-200 mg/day. A small double-blind crossover trial has explored whether higher carbidopa doses are clinically useful (Nutt et al. AAN 2012; abstract S02.006).

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The caveat is that higher carbidopa doses have the potential to inhibit amino acid decarboxylase and reduce dopamine formation in the striatum.

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