The latest claimant to the neuroprotection crown is green tea, which provides therapeutic levels of the antioxidant EGCG (epigallocatechin gallate). A number of animal studies have indicated that EGCG may be beneficial in a range of disorders, including arthritis, colitis, Sjogren’s syndrome, and type 1 diabetes (Kim et al. J Nutr 2008;138:2111-2116; Oz et al. J Nutr Biochem 2005;16:297-304; Hsu et al. Autoimmunity 2007;40:138-147; Fu et al. Br J Nutr 2011;105:1218-1225).
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The woes of neurology drug development: Eli Lilly
November 21, 2012The difficulties of developing new therapies for neurological disorders is well documented (see CNS drug development: a pipeline of problems, Neurosens, November 9, 2011). The most recent case in point: Eli Lilly, which has had a tough summer with two of its late-stage drugs.
Testing the new NIA-AA criteria for MCI
November 21, 2012A European group has examined the risk of progression to Alzheimer’s disease for the four MCI subgroups outlined in the National Institute on Aging-Alzheimer’s Association (NIA-AA) recommendations (Guo et al. Eur Arch Psychiatry Clin Neurosci 2012; epublished August 30, 2012).
GDS recommended for depression screening in PD
November 21, 2012The Methods of Optimal Depression Detection in Parkinson’s Disease (MOOD-PD) study has reviewed patient self-report scales, concluding that the 30-item Geriatric Depression Scale (GDS) is the most efficient tool to screen for clinical depression in PD patients (Williams et al. Neurology 2012;78:998-1006).