A new study has reported that the kappa free light chain index (K-index) can predict the occurrence of new T2 lesions in subjects with clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) (Levraut et al. Neurol Neuroimmunol Neuroinflamm 2023;10:e200156). The K-index was also useful to predict clinical events in CIS. Read More
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TERIS trial: final results
September 7, 2023The TERIS trial of teriflunomide in individuals with radiologically isolated syndrome (RIS) has reported that treatment significantly prolonged the time to a first clinical event by 63% versus placebo (Lebrun-Frenay et al. JAMA Neurol, epublished August 21, 2023). Read More
New ECTRIMS/EAN recommendations for vaccination in MS patients
September 5, 2023The European Committee for Treatment and Research in MS (ECTRIMS) and the European Academy of Neurology (EAN) have published their first recommendations on vaccination in people with MS (Otero-Romero et al. Eur J Neurol 2023;30:2144-2176). The following is a summary of key recommendations for patients receiving higher-efficacy disease-modifying therapies (DMTs). Read More
MicroRNAs – their potential as MS biomarkers
August 29, 2023MicroRNAs are short (21-25 nucleotides) non-coding RNA molecules that regulate gene expression by activating or repressing mRNA transcription. About 2000 have been identified thus far (Kozomara et al. Nucleic Acids Res 2019;47:155-162), and many have potential utility as biomarkers in the diagnosis, monitoring and treatment of multiple sclerosis. Read More