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Treatment optimization in MS – new Canadian recommendations

May 15, 2020

…ven years ago (Freedman et al. Can J Neurol Sci 2013;40:307-323). The 16 recommendations encompass risk stratification, criteria for switching patients with an inadequate response, cognitive testing, and treatment of pediatric-onset MS. The consensus recommendations were developed by 31 Canadian neurologists with expertise in MS. The current version provides criteria for switching RRMS patients with an inadequate response to a disease-modifying th…

Vaccines in development for COVID-19

May 5, 2020

…e may become available in early 2021. For a recent review see Amanat et al. Immunity 2020;52; epublished April 14, 2020. Free full text at www.cell.com/immunity/pdf/S1074-7613(20)30120-5.pdf….

COVID-19 – FDA approves hydroxychloroquine amid controversy

April 9, 2020

…microb Agents 2020 ; epublished March 20, 2020 ; free full text at https://www.sciencedirect.com/science/article/pii/S0924857920300996/pdfft?md5=332491a1ab112f0e0058fb400a5ea8ca&pid=1-s2.0-S0924857920300996-main.pdf). There was a significant difference in nasopharyngeal viral load beginning on Day 3 and continuing to Day 6. At Day 6, the virological cure rate was 100% with hydroxychloroquine/azithromycin, 57% with hydroxychloroquine monotherapy an…

MS treatment recommendations during COVID-19 pandemic

March 30, 2020

…after the pandemic recedes. Click here to access the Canadian Network recommendations: https://cnmsc.ca/Announcements Click here to access the ABN recommendations: https://cdn.ymaws.com/www.theabn.org/resource/collection/6750BAE6-4CBC-4DDB-A684-116E03BFE634/ABN_Guidance_on_DMTs_for_MS_and_COVID19_APPROVED_11_March.pdf…

FDA approves compassionate use of Ecstasy

January 29, 2020

…ls. There was a non-significant improvement in depression scores. The most common adverse effects were anxiety, jaw clenching, headache, fatigue and lack of appetite. Serious adverse effects were suicidal ideation, suicidal behaviour and exacerbation of ventricular extrasystoles (one case each). Two small phase III trials are now ongoing with results expected next year. Most of the MDMA studies to date have been funded by the Multidisciplinary Ass…