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ACTRIMS-ECTRIMS 2020 HIGHLIGHTS – SATURDAY, SEPTEMBER 12 EDITION

September 12, 2020

…onth 3. The results indicate that there is a therapeutic effect before the complete two-year course of cladribine is completed. Sequencing has effects on Ig Concerns have been raised about the possible effects on immune competence of sequential disease-modifying therapies. A study compared whole-blood samples from 133 RRMS patients (aged 17-66 years) versus patients with other neurological conditions and healthy controls (Keiner et al. ECTRIMS 202…

Molecular profiling of slowly expanding MS lesions

August 12, 2020

…le et al. Brain 2020;143:2073-2088; free full text at https://academic.oup.com/brain/article-pdf/143/7/2073/33502654/awaa158.pdf). SELs are considered the pathological correlate of MS disease progression. The post-mortem study examined 21 SELs (mixed active/inactive and demyelinating lesions) from 13 patients with progressive MS aged 30-74 years. Additional tissue samples (chronic inactive lesions, normal-appearing white matter) were also examined…

The overlooked role of T cells in the antiviral response

July 21, 2020

…obust CD4+/CD8+ response (Sahin et al. medRxiv preprint. Free full text at www.medrxiv.org/content/10.1101/2020.07.17.20140533v1.full.pdf). Interestingly, Grifoni and colleagues also reported that 50% of individuals with no exposure to SARS-CoV-2 showed non-Spike-specific CD4+ T cell reactivity. This suggests some degree of cross-reactivity, raising the possibility that individuals who have been exposed to other coronaviruses (e.g. the common cold…

Neurofilament-light – Update from EAN

July 14, 2020

…s and 8.8 pg/mL in PPMS patients treated with ocrelizumab. Results for the comparator groups (interferon-beta; placebo) in OPERA/ORATORIO were not available. The OBOE (Ocrelizumab Biomarker Outcome Evaluation) trial of RMS and PPMS reported a reduction in CSF NfL concentrations of 24% at 12 weeks and 47% at 24 weeks with ocrelizumab (Bar-Or et al. AAN 2020; abstract S24.002). A longer follow-up of the PPMS cohort found no decrease in NfL (CSF or s…

Update on B cells in MS pathophysiology

June 29, 2020

…fering effects on the proliferation of B cells and plasma cells in the CNS compartment and the release of neurotoxic soluble factors that appear to drive disease progression in MS. Part 2 will examine the latest data on the effect of current and emerging anti-CD20 therapies on clinical outcomes in MS. Survey 1. To control MS disease activity, do you think it’s more important to target: T cells B cells Both T and B cells Cells of innate immune syst…