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Three biomarkers of DMT adverse effects proposed

August 25, 2022

…was 75%. Further reading: Kreft et al. Free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC9363281/pdf/415_2022_Article_11300.pdf Diebold et al. Free full text at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314128/pdf/ANA-91-676.pdf Mahler et al. Free full text at https://academic.oup.com/brain/article/144/9/2683/6184141 Walo-Delgado et al. Free full text at https://www.frontiersin.org/articles/10.3389/fimmu.2021.760546/full…

CLINICAL CASES IN MS – CASE 6: DIAGNOSTIC DILEMMA

August 22, 2022

…ntermittent therapy to minimize the duration of immune suppression (14%). None of the respondents would choose a DMT based on its putative antiviral effects. View the video commentary by Dr. Virender Bhan. https://www.youtube.com/watch?v=-COEt0nb0Nk Additional reading: Vidal-Jordana et al. Optic Nerve Topography in Multiple Sclerosis Diagnosis: The Utility of Visual Evoked Potentials. Neurology 2021;96:e482-e490….

COVID update: the 7th wave

July 13, 2022

…canada/toronto/ontario-covid-19-ba5-wave-1.6512283). As of June 19, 81.9% of Canadians had completed a primary series of COVID vaccinations and 48.9% had received one booster injection. For the fall, the National Advisory Committee on Immunization (NACI) recommends a booster shot for all at-risk groups; a booster may also be offered to individuals aged 12-64 years. Quebec is now recommending a fourth dose for all persons aged >60 years….

EAN 2022 HIGHLIGHTS – TUESDAY, JUNE 28 EDITION

June 28, 2022

…aking a DMT (primarily interferon-β, glatiramer acetate and azathioprine). Comorbidity (cardiovascular, orthopedic, metabolic/endocrine) was common (87%). A second study of MS patients at a tertiary-care neurology unit reported that 18.9% were aged >60 years (De Lorenzo et al. EAN 2022; EPO-192). Median EDSS score in this group was 4.0; median EDSS score was 2.5 for RRMS, 6.5 for SPMS and 6.0 for PPMS. Mean relapse-free time was 13 years. A total…

Bivalent boosters in development for COVID-19

June 21, 2022

…lable as a preprint only (Chalkias et al. Research Square, April 15, 2022; free full text at file:///D:/May%202022/Moderna_bivalent%20vaccine.pdf). The geometric mean neutralizing antibody titre (GMT) was two-fold higher against the Omicron variant with the mRNA-1273.211 bivalent booster versus the original mRNA-1273 booster at 28 days (GMT 1380.8 vs. 630.5) and 180 days post-injection (GMT 312.9 vs. 145.6). The most common systemic adverse reacti…