Short-term adherence to migraine prophylaxis is poor, with about one-half of patients stopping their medication within a year, according to the results of a systematic review (Hepp et al. J Manag Care Pharm 2014;20:22-33). Read More
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Augmentation in treatment-resistant depression: meta-analyses
October 8, 2014A number of systematic reviews have investigated the optimal approach in treatment-resistant depression (TRD), but the conclusions are somewhat inconsistent and clinical opinion appears to be evolving. Read More
Combining drug and psychotherapy more effective for depression, anxiety
September 24, 2014A new meta-analysis has concluded that combining psychotherapy with pharmacotherapy is more effective than either treatment alone in managing patients with major depression, panic disorder or obsessive-compulsive disorder (Cuijpers et al. World Psychiatry 2014;13:56-67; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3918025/pdf/wps0013-0056.pdf). Read More
New data for daclizumab in MS
September 24, 2014Daclizumab is an IgG1 anti-CD25 monoclonal antibody that blocks IL-2-mediated lymphocyte activation. The drug (Zenapax) was originally used to prevent tissue rejection but was withdrawn by Roche in 2009 due to declining demand. Read More