A new meta-analysis of 39 studies (n=10,864) has concluded that there is an association between Epstein-Barr virus (EBV) seropositivity and MS (Almohmeed et al. PLoS One 2013;8:e61110; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3621759/pdf/pone.0061110.pdf). Seroprevalence was determined for three anti-EBV antibodies: anti-EBV nuclear antigen 1 (anti-EBNA-1) or EBNA complex; antiviral capsid antigen (anti-VCA); and anti-Early Antigen (anti-EA). Read More
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Depression and discrimination: the ASPEN/INDIGO study
February 19, 2014A large multinational study has found that a majority of individuals with major depressive disorder have experienced some form of discrimination (Lasalvia et al. Lancet 2013; 381: 55–62). The study was a collaborative effort by 18 countries participating in the Anti Stigma Programme European Network (ASPEN), and 17 countries involved in the International Study of Discrimination and Stigma for Depression (INDIGO). Read More
Subthalamic stimulation useful for early motor complications
February 19, 2014A number of studies have demonstrated that deep-brain stimulation (DBS) can improve mobility, ADLs and QOL measures in patients with advanced PD with severe motor complications (Deep-Brain Stimulation for Parkinson’s Disease Study Group. N Engl J Med 2001;345:956-963. Deuschl et al. N Engl J Med 2006;355:896-908; free full text at www.nejm.org/doi/pdf/10.1056/NEJMoa060281). Read More
Clinical Issues in Multiple Sclerosis
December 12, 2013Issues in Multiple Sclerosis
Early diagnosis, identification of non-responders and brain atrophy in MS
Professor Xavier Montalban, MD, PhD
Professor of Neurology
Universitat Autònoma de Barcelona (UAB)
Director, Multiple Sclerosis Centre of Catalonia
Head, Neuroimmunology Group
Vall d’Hebron Institute of Research
Barcelona, Spain Read More