A large multinational study has found that a majority of individuals with major depressive disorder have experienced some form of discrimination (Lasalvia et al. Lancet 2013; 381: 55–62). The study was a collaborative effort by 18 countries participating in the Anti Stigma Programme European Network (ASPEN), and 17 countries involved in the International Study of Discrimination and Stigma for Depression (INDIGO). Read More
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Subthalamic stimulation useful for early motor complications
February 19, 2014A number of studies have demonstrated that deep-brain stimulation (DBS) can improve mobility, ADLs and QOL measures in patients with advanced PD with severe motor complications (Deep-Brain Stimulation for Parkinson’s Disease Study Group. N Engl J Med 2001;345:956-963. Deuschl et al. N Engl J Med 2006;355:896-908; free full text at www.nejm.org/doi/pdf/10.1056/NEJMoa060281). Read More
Clinical Issues in Multiple Sclerosis
December 12, 2013Issues in Multiple Sclerosis
Early diagnosis, identification of non-responders and brain atrophy in MS
Professor Xavier Montalban, MD, PhD
Professor of Neurology
Universitat Autònoma de Barcelona (UAB)
Director, Multiple Sclerosis Centre of Catalonia
Head, Neuroimmunology Group
Vall d’Hebron Institute of Research
Barcelona, Spain Read More
MS treatment: What is Plan B?
December 5, 2013
Comment by Dr. Paul Steven Giacomini
NeuroSens survey on sequencing
The year 2013 was the twentieth anniversary of the first published trial of a disease-modifying therapy (DMT) in multiple sclerosis, an occasion marked by the arrival of two new oral agents in an expanding armamentarium of MS therapies. Teriflunomide got the green light in Canada and Europe (previously approved in the U.S.); and dimethyl fumarate (DMF) was approved in Canada and the U.S. (but is still pending in Europe).
Laquinimod, fast-tracked by the FDA four years ago, appears to be idling at the curb. Read More