A meta-analysis has concluded that amyloid-beta1-42 in CSF is useful for discriminating Alzheimer’s disease from controls (Rosa et al. J Alzheimers Dis 2014; epublished January 21, 2014). Read More
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Long-acting injectable aripiprazole approved in Canada
August 13, 2014Aripiprazole data summary: efficacy and safety results
Underutilization of LAIs
Commentary by Dr. Ofer Agid, Centre for Addiction and Mental Health, Associate Professor of Psychiatry, University of Toronto, Toronto, Canada.
A once-monthly long-acting injectable (LAI) formulation of aripiprazole (Abilify Maintena; Otsuka Pharmaceuticals Canada Inc.) has now been approved by Health Canada for maintenance treatment of adult patients with schizophrenia.
It is the first partial dopamine agonist to become available as an LAI. Aripiprazole once-monthly (OM) was previously approved by the U.S. Food and Drug Administration in February 2013. Read More
Sleep disorder in PD: a role for circadian rhythm disturbance?
August 6, 2014Sleep disorders are a non-motor symptom reported to occur in most PD patients at some stage of the disease. In newly-diagnosed PD, sleep disturbances appear to be uncommon although subjects may reported daytime naps and dream-related behaviours (Prudon et al. Mov Disord 2014;29:259-263).
Later in the disease course, sleep disorders may be due to neurodegenerative changes or secondary to drug treatment. Associated disorders may include restless legs syndrome, REM sleep behaviour disorder, and obstructive sleep apnea (Schulte & Winkelmann. J Neurol 2011;258(suppl 2):S328-335). Read More
New dosing for glatiramer acetate
August 6, 2014The U.S. Food and Drug Administration has approved high-dose glatiramer acetate (40 mg/day) with a new three times per weekly dose schedule. Read More