REPORT FROM THE ENS 2008 – Ibudilast (MN-166, AV-411), a nonselective phosphodiesterase inhibitor, may provide some degree of neuroprotection following acute MS lesion formation, according to a retrospective analysis of MRI data from the MN-166 CL-01 study (Gammans et al. Abstract 0191. J Neurol 2008;255(suppl 2): 45).
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Neurology
Zonisamide pilot study in PD-associated impulse control disorders
October 21, 2008REPORT FROM THE ENS 2008 – Zonisamide (Zonegran) is a sulfonamide anticonvulsant used as an adjunctive therapy in epilepsy.
PROCESS study of spinal cord stimulation: 24-month data
October 8, 2008REPORT FROM THE ENS 2008 – The Canadian PROCESS study compared spinal cord stimulation (SCS) plus conventional medical management (CMM) to CMM alone in 100 patients with predominant neuropathic leg pain secondary to failed back surgery syndrome (Kumar et al. Pain 2007;132:179-188).
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LDL targets not met with statins post-stroke
October 7, 2008REPORT FROM THE ENS 2008 – The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial demonstrated that atorvastatin 80 mg/day was effective in secondary prevention of ischemic stroke or TIA. At 4.9-year median follow-up, the absolute risk reduction for ischemic stroke with atorvastatin versus placebo was 2.2% (adjusted HR 0.78), although more hemorrhagic strokes occurred in the active treatment group (55 vs. 33; adjusted HR 1.66) (Amarenco et al. N Engl J Med 2006;355:549-59).
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Beta-interferons in CIS: Cochrane meta-analysis
September 23, 2008REPORT FROM THE ENS 2008 – Beta-interferons are effective in preventing the conversion of clinically isolated syndrome (CIS) suggestive of MS to clinically definite MS, according to the results of a Cochrane meta-analysis (Clerico et al. Abstract 0160. J Neurol 2008;255(suppl 2): 37; published as Clerico et al. Cochrane Database Syst Rev 2008;April 16(2):CD005278).
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