Several recent studies have examined the clinical significance of oligoclonal bands (OCB) in cerebrospinal fluid, which are present in about 75-95% of MS patients of European descent.
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Neurology
Apathy associated with cognitive decline in AD, MCI
May 5, 2009Two recent studies in France have indicated that apathy may be an indicator of cognitive declines in patients with mild cognitive impairment (MCI), and of functional decline in those with Alzheimers disease.
Parkinson motor score higher with suboptimal adherence
April 21, 2009Medication adherence in Parkinsons disease patients may be poor as a result of motor symptoms, complex dosing regimens, the need for multiple medications and patients lack of awareness about the clinical impact of poor adherence.
Pneumonia a common cause of death in dementia patients
April 21, 2009Bronchopneumonia and ischemic heart disease are the most common causes of death among dementia patients, according to a review of autopsy reports at University Hospital, Lund, Sweden (Brunnstrom & Englund. Eur J Neurol 2009; epublished January 26, 2009).
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Phase I/II study of non-myeloablative SCT in RRMS
April 12, 2009Researchers in Chicago have conducted a phase I/II trial of autologous non-myeloablative hematopoietic stem cell transplantation (SCT) in 21 relapsing-remitting MS patients (Burt et al. Lancet Neurol 2009; epublished January 29, 2009). All subjects had experienced >2 steroid-treated relapses or 1 relapse with Gd-enhancing lesions in the previous 12 months despite treatment with a beta-interferon.