REPORT FROM THE ENS 2008 – Beta-interferons are effective in preventing the conversion of clinically isolated syndrome (CIS) suggestive of MS to clinically definite MS, according to the results of a Cochrane meta-analysis (Clerico et al. Abstract 0160. J Neurol 2008;255(suppl 2): 37; published as Clerico et al. Cochrane Database Syst Rev 2008;April 16(2):CD005278).