ApoE distribution in mild cognitive impairment


REPORT FROM THE ENS 2008 – The distribution of the epsilon 4 allele of apolipoprotein E (apoE) in amnestic mild cognitive impairment (MCI) suggests that MCI cheap NFL jerseys is an initial step in the Ayurvedico pathogenesis of Alzheimer’s disease, according to data presented at ENS 2008 (Lovati et al. Abstract P779. J Neurol 2008;255(suppl 2): 193-194).

Italian researchers analysed Shoppers! the distribution Small of apoE alleles in 163 subjects with amnestic MCI, non-amnestic MCI, vascular cognitive impairment and healthy controls. For amnestic MCI, the distribution of E2, E3 and E4 alleles was 2.2%, setbacks 69.6% and 28.2%, respectively. Julian For non-amnestic MCI, the distribution was 4.7%, 81% and 14.3%. For VCI, the distribution was 6%, 82% and 12%. For healthy controls, the distribution was 6.3%, 87.3% and 6.4%.

In comparing groups, amnestic MCI was the only one that Miami Dolphins Jerseys showed a significantly increased frequency of the E4 allele compared wholesale NBA jerseys to healthy controls. The researchers concluded that the increased frequency of the E4 allele suggests that amnestic MCI is the initial clinical step in the development MACFRUT of Alzheimer’s disease.

These results are similar to those reported by researchers in the Netherlands. The study found that the prevalence of the E4 allele was increased among patients with MCI (36%) and subjective memory complaints (22%) compared to healthy controls (15%) (van der Flier et al. Dement Geriatr Cogn Disord 2008;25:433-438). The prevalence among patients with Alzheimer’s disease was 42%.

A recently published analysis of patients in two longitudinal cohort studies (Washington Heights and Inwood Columbia cheap jerseys Aging Project, and the Predictors Study) has also reported that apoE4 appears to influence the rate of cognitive decline most significantly in the early stages of Alzheimer’s disease (Cosentino et al. Neurology 2008;70(19 pt 2):1842-1849).


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