A Canadian/U.S. randomized controlled trial reports that patients with dementia with Lewy bodies (DLB) treated with risperidone or citalopram do not tolerate the medications and appear to obtain little benefit (Culo et al. Alzheimer Dis Assoc Disord 2010; epublished July 9, 2010). This is the first published trial to examine the effect of citalopram in DLB.