ACTH revisited: melanocortins and MS

 

 

Melanocortin system
Immune effects of ACTH-MCR interactions
ACTH vs. steroids
Commentary by Dr. Daniel Selchen, University of Toronto, Canada
NeuroSens Survey

A few decades ago, adrenocorticotropic hormone (ACTH) was routinely used for managing acute relapses in patients with multiple sclerosis. The efficacy of this approach was demonstrated in what was perhaps the first multicentre placebo-controlled study in MS, which also introduced the Disability Status Scale (DSS) as an endpoint (Rose et al. Trans Am Neurol Assoc 1969;94:126-133).

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