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Phase I/II study of non-myeloablative SCT in RRMS

Researchers in Chicago have conducted a phase I/II trial of autologous non-myeloablative hematopoietic stem cell transplantation (SCT) in 21 relapsing-remitting MS patients (Burt et al. Lancet Neurol 2009; epublished January 29, 2009). All subjects had experienced >2 steroid-treated relapses or 1 relapse with Gd-enhancing lesions in the previous 12 months despite treatment with a beta-interferon. Subscribe to read more It takes 30 seconds or logi…

Switching MS therapies effective after treatment failure

…For multiple sclerosis patients who fail to respond to a first-line disease-modifying treatment (DMT), switching to another DMT is a generally effective strategy, according to an analysis by U.S. and Italian researchers (Gajofatto et al. Mult Scler 2009;15:50-58). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…

Benign paroxysmal positional vertigo: new guidelines

…The American Academy of Otolaryngology-Head and Neck Surgery Foundation have published guidelines for the clinical management of benign paroxysmal positional vertigo (BPPV) (Bhattacharyva et al. Otolaryngol Head Neck Surg 2008;139(5 suppl 4):S47-S81). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…

Managing patients with severe Alzheimer disease

…tine, and atypical antipsychotics for patients with severe agitation, aggression and psychosis, according to the Third Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (Herrmann & Gauthier. Can Med Assoc J 2008;179:1279-1287; free text at www.cmaj.ca/cgi/content/full/179/12/1279. See also Patterson et al. Can Med Assoc J 1999;160:1738-1742). Subscribe to read more It takes 30 seconds or login using your email address Please…

Anticholinergic drug use may be associated with cognitive decline

…REPORT FROM THE 133rd AMERICAN NEUROLOGICAL ASSOCIATION MEETING – Anticholinergic agents (e.g. tolterodine, oxybutynin) are frequently prescribed in the elderly but may produce an accelerated cognitive decline, according to a U.S. study (Janos et al. Abstract T-35). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…