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Variable vaccine efficacy against CoV-2 variants

…tical COVID (Haas et al. Lancet 2021; epublished 5 May 2021; www.thelancet.com/action/showPdf?pii=S0140-6736%2821%2900947-8). The estimated prevalence of the UK variant (B.1.1.7) at the time of the study was 94.5% of samples, indicating that efficacy against the variant was comparable to what has been reported against the pandemic strain (D614G variant). The UK variant has been associated with a higher risk of mortality (hazard ratio 1.67) (Grint…

mRNA vaccines preferred: new NACI recommendation

…et (www.canada.ca/en/public-health/services/immunization/national-advisory-committee-on-immunization-naci/recommendations-use-covid-19-vaccines.html). The controversial recommendation states that an mRNA COVID-19 vaccine should be preferentially offered to individuals. The AstraZeneca COVID-19 vaccine may be offered to people aged >30 years only if the individual does not wish to wait for an mRNA vaccine. Individuals are advised to do their own be…

Thrombotic risk and COVID-19 vaccines: new data and disputes

…care products Regulatory Agency (Williams S. The Scientist, 16 April 2021; www.the-scientist.com/news-opinion/blood-clot-risk-from-covid-19-higher-than-after-vaccines-study-68675). It should be noted that the thrombotic complications linked to COVID vaccination are, in part, a subset of CVT that occur in the setting of thrombocytopenia, a syndrome that has been labelled vaccine-induced prothrombotic immune thrombocytopenia (VIPIT, or VITT). The CD…

COVID variants: is one dose better than nothing?

…ach added, “we could be wrong.” (Serebrin J. Canadian Press, 2 March 2021. www.thestar.com/news/canada/2021/02/03/fear-that-delayed-second-covid-19-vaccine-dose-could-lead-to-new-variants-realistic.html). How these variants have emerged has not been determined. The pandemic strain (D614G) is a variant that supplanted the Wuhan strain and soon became dominant due to enhanced infectivity of the upper respiratory tract (Plante et al. Nature 2021;592:…

Few vaccine responders with fingolimod, ocrelizumab

…result of these findings, the group is updating its COVID-19 vaccination recommendations to state that untreated MS patients can be vaccinated without limitations and cladribine-treated patients should be vaccinated at least 4.4 months after the last dose. The group does not promote COVID-19 vaccination in fingolimod-treated patients unless the lymphocyte count is >1.0, with the caveat that ALC is not correlated with a protective humoral response….